Article ID Journal Published Year Pages File Type
3170097 Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 2006 6 Pages PDF
Abstract

ObjectiveThe purpose of this study was to investigate the relationship between type 2 diabetes mellitus and anaerobic bacteria detected in infected root canals.Study designNormal Wistar rats (control) received a standard laboratory diet with water (group A), and GK rats (type 2 diabetes mellitus rats) a normal laboratory diet with water (group B) or a 30% sucrose solution (group C). Chemotaxis assay was conducted on polymorphonuclear leukocytes from the 3 groups, and the numbers of anaerobic bacteria in infected root canals were determined.ResultsIn the chemotaxis assay on the polymorphonuclear leukocytes, the chemotactic response of cells in group C was lower than that for groups A and B (P < .01). As to bacteria detected in the root canal, obligate anaerobic bacteria which stained gram negative, were significantly more numerous in group C (P < .01) than in groups A and B.ConclusionThe metabolic condition produced by type 2 diabetes mellitus in rats might lower the general host resistance against bacterial infection.

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Health Sciences Medicine and Dentistry Dentistry, Oral Surgery and Medicine
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