Article ID Journal Published Year Pages File Type
3171786 Pediatric Dental Journal 2007 6 Pages PDF
Abstract

This study examined the effect of tube feeding on hippocampal Fos induction and spatial performance in a water maze task in senescenceaccelerated mice (SAMP1). Tube feeding accelerated the age-related decline in spatial memory and decreased Fos induction in the hippocampal CA1 region in aged SAMP1 mice. The results suggest that tube feeding in aged SAMP1 mice reduces input activity in the hippocampus, thereby leading to senile memory deficits.

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