Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3177384 | Sleep Medicine | 2011 | 8 Pages |
Abstract
The concept of Agrypnia excitata (AE) was originally proposed as a concept deriving from the clinical and anatomo-pathological observations obtained in three different diseases, Fatal familial insomnia (FFI), Delirium tremens (DT), and Morvan syndrome (MS). Agrypnia refers to a condition of severely reduced or absent sleep due to organic disorders. Excitata refers to the association of agrypnia with generalized motor and autonomic hyperactivation. AE is a syndrome that has been claimed to relate to a dysfunction in the thalamo-limbic circuits that govern sleep–wake cycles and autonomic activities.
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Authors
Elio Lugaresi, Federica Provini, Pietro Cortelli,