| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3178141 | Sleep Medicine | 2007 | 6 Pages |
Abstract
BackgroundThe hypothalamic neuropeptide hypocretin (orexin) modulates sleep–wake, feeding and endocrine functions. Cerebrospinal fluid (CSF) hypocretin-1 (Hcrt-1) concentrations are low in patients with narcolepsy–cataplexy, a sleep disorder characterized by hypersomnolence and rapid eye movement (REM) sleep abnormalities.MethodsWe determined CSF Hcrt-1 concentrations of patients with the fibromyalgia syndrome (FMS), a condition characterized by fatigue, insomnia and in some cases daytime hypersomnolence.ResultsBasal CSF levels of Hcrt-1 in FMS did not differ from those in healthy normal controls.ConclusionsThese findings suggest that abnormally low Hcrt-1 is not a likely cause of fatigue in FMS.
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Authors
Oludare B. Taiwo, I. Jon Russell, Emmanuel Mignot, Ling Lin, Joel E. Michalek, Wanda Haynes, Yangming Xiao, Jamie M. Zeitzer, Alice A. Larson,