Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3180677 | Actas Dermo-Sifiliográficas | 2012 | 4 Pages |
Abstract
Giant basal cell carcinoma (BCC) is defined as a tumor with a diameter of 5Â cm or more. Surgery, the treatment of choice for any type of BCC, can cause considerable anatomical damage in large tumors. In 2 patients with giant BCC we therefore provided neoadjuvant treatment with a combination of oral acitretin and topical 5% imiquimod. Acitretin is a systemic retinoid used for primary prevention of nonmelanoma skin cancer. Imiquimod is an immunomodulator whose approved indications include treatment of nonfacial superficial BCC less than 2Â cm in diameter. Previous studies have demonstrated a synergic anticancer effect of both drugs in vitro and in vivo. This combination produced a marked reduction in tumor mass in our patients. Later we were able to provide definitive treatment, which achieved complete remission of the tumors.
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Authors
V. SanmartÃn, R. Aguayo, M. Baradad, J.M. Casanova,