| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3185573 | Annales de Dermatologie et de Vénéréologie | 2016 | 5 Pages |
Abstract
The GGCX gene is usually responsible for PXE-like syndrome. GGCX encodes a γ-glutamyl carboxylase necessary for activation of gla-proteins. Gla-proteins are involved both in coagulation factors in the liver and in the prevention of ectopic mineralization of soft tissues. Uncarboxylated forms of gla-proteins in fibroblast would thus enable mineralization and fragmentation of elastic fibers.
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Authors
L. Gusdorf, M. Mitcov, S. Maradeix, S. Cunat, L. Martin, B. Cribier,