Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3188476 | Annales de Dermatologie et de Vénéréologie | 2009 | 4 Pages |
Abstract
Although the precise aetiology is unknown, the development of eruptive keratoacanthomas is associated with impaired immunity, sun exposure, viral infection, genetic predisposition, radiation therapy and exposure to chemical carcinogens. A few cases of drug-induced keratoacanthomas have been described in the literature and certain immunosuppressant drugs have been implicated. This case suggests that the novel antineoplastic agent sorafenib has a complex activity that, in addition to tyrosine kinases inhibition, includes an immunosuppressant mechanism that can occasionally cause skin lesions.
Keywords
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Authors
H. Jantzem, D. Dupre-Goetghebeur, P. Spindler, J. Merrer,