Article ID Journal Published Year Pages File Type
3188476 Annales de Dermatologie et de Vénéréologie 2009 4 Pages PDF
Abstract
Although the precise aetiology is unknown, the development of eruptive keratoacanthomas is associated with impaired immunity, sun exposure, viral infection, genetic predisposition, radiation therapy and exposure to chemical carcinogens. A few cases of drug-induced keratoacanthomas have been described in the literature and certain immunosuppressant drugs have been implicated. This case suggests that the novel antineoplastic agent sorafenib has a complex activity that, in addition to tyrosine kinases inhibition, includes an immunosuppressant mechanism that can occasionally cause skin lesions.
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Health Sciences Medicine and Dentistry Dermatology
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