| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3190999 | Annals of Allergy, Asthma & Immunology | 2015 | 11 Pages |
Abstract
Mucosal eosinophilia seems to be induced by EO nasal trapping through modulation of adhesion receptors. In patients with asthma, EO involvement is enhanced by the antiapoptotic synergistic action of T-helper cell type 2 cytokines on IL-5Rα expression. This study shows for the first time that IL-9 is involved in EO homeostasis in CRSwNP and could explain the low benefit of anti-IL-5 therapy for some patients with asthma and nasal polyposis.
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Authors
Geoffrey MD, Isabelle MD, Claire MD, Marie Delbeke, Solène PharmD, Dominique MD, Lionel MD, PhD, Monique PharmD, PhD,