Mannitol as an indirect bronchoprovocation test for the 21st century

Mannitol is a polyol sugar that can be converted to a powdered form and encapsulated. Once encapsulated it can be inhaled and causes narrowing of the airways in susceptible individuals. Mannitol likely triggers the release of inflammatory and/or bronchospasm mediators, causing the smooth muscle of the airway to contract and resulting in airway narrowing. The magnitude of decrease in forced expiratory volume in 1 second and the dose of mannitol needed to provoke the airway response provide a readily measurable and clinically useful assessment of airway hyperreactivity. Mannitol challenge is an accepted testing method in Australia, Europe, and Korea. Acceptance of the mannitol challenge in the United States would complement existing methods for assessing bronchial hyperreactivity and likely improve patient care.