| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3193632 | Annals of Allergy, Asthma & Immunology | 2006 | 7 Pages |
Abstract
Sulfite, the aqueous ion of sulfur dioxide, induces cellular activation, leading to degranulation in mast cells through a non-IgE-dependent pathway. The response also differs from IgE-mediated degranulation in that it is insensitive to the influx of extracellular calcium. The putative pathway seems to rely on activation of the reduced form of nicotinamide adenine dinucleotide phosphate oxidase complex, leading to intracellular oxidative stress.
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Authors
Christopher R. MD, PhD, Daniel J. MS, Randall M. MD, Edward G. MD,