Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3194016 | Clinics in Dermatology | 2015 | 4 Pages |
Abstract
Skin is often affected in adverse drug reactions. Although the majority of cutaneous adverse drug reactions are benign and self-limiting, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS), affecting multiple organs and systems, are potentially fatal. Many organs can be affected, including the mucosal membranes, gastrointestinal tract, liver, lungs, kidneys, and eyes. We discuss the causes, pathophysiologic aspects, and main clinical features of SJS, TEN, and DRESS as systemic diseases with skin involvement.
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Authors
Razvigor Darlenski, Jana Kazandjieva, Nikolai Tsankov,