Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3194334 | Clinics in Dermatology | 2013 | 5 Pages |
Abstract
There is now scientific evidence of genetically driven skin-barrier anomalies in atopic patients. These barrier anomalies facilitate sustained antigen ingress through the defective barrier, which can bring about a Th2-dominant response. It enhances the transepidermal water loss, resulting in dry skin and leading to the release of preformed proinflammatory cytokines and to a cascade of events ending up in inflammation.
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Authors
Ronni Wolf, Lawrence Charles Parish,