| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3194618 | Clinics in Dermatology | 2010 | 5 Pages |
Abstract
The pathophysiology of atopic dermatitis is still under discussion. Although it is widely accepted that environmental factors and a genetic predisposition are essential, the role of the innate and adaptive immune system and the functional cascade of the cells involved is still unclear. A concept that integrates all immune cells as equally essential has allure. In addition, barrier abnormalities due to mutations of the gene coding for filaggrin and down-regulation of antimicrobial peptides, such as LL-37 and β-defensins 2 and 3, were very recently found to be relevant for the pathogenesis of atopic dermatitis.
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Authors
Rudolf A. Rupec, Susanne Boneberger, Thomas Ruzicka,