Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3195070 | Clinics in Dermatology | 2006 | 7 Pages |
Abstract
Multicentric reticulohistiocytosis is a rare granulomatous disease of unknown etiology, characterized by cutaneous nodules and destructive arthritis. Skin lesions can cause significant deformity, and approximately half of affected patients develop a severe disabling arthritis. The disease is often associated with malignancy; however, the paraneoplastic nature of multicentric reticulohistiocytosis is not established. The diagnosis is confirmed by the presence of oncocytic (“ground-glass”) histiocytes and multinucleated giant cells on histopathology of the cutaneous nodules and the synovial membrane.
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Authors
Ani L. Tajirian, Mohsin K. Malik, Leslie Robinson-Bostom, Edward V. Lally,