| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3197493 | Journal of Allergy and Clinical Immunology | 2014 | 9 Pages |
Abstract
Exposure to CS is associated with reduced 25VD3 levels and an impaired ability of HSNECs to convert 25VD3 to 1,25VD3. Addition of 1,25VD3 reduces the proinflammatory effects of CS on HSNECs. Impaired VD3 conversion by CS exposure represents a novel mechanism through which CS induces its proinflammatory effects.
Keywords
CSECRSsNPVD3CRSwNPVDRBEGMETsCRS25-hydroxycholecalciferol1α,25-dihydroxyvitamin D3cycle thresholdSecondhand smokeCigarette smokeenvironmental tobacco smokeChronic rhinosinusitis with nasal polypsChronic rhinosinusitis without nasal polypsChronic rhinosinusitisepithelial cellDendritic cellcigarette smoke extractVitamin D3Vitamin DSinusitisVitamin D receptor
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Authors
Jennifer K. PhD, Whitney BS, Brendan P. MD, Jennifer BS, Carl PhD, Rodney J. MD,