Loss of regulator of G protein signaling 5 promotes airway hyperresponsiveness in the absence of allergic inflammation

Article ID	Journal	Published Year	Pages	File Type
3197506	Journal of Allergy and Clinical Immunology	2014	20 Pages	PDF

Abstract

Loss of RGS5 confers spontaneous AHR in mice in the absence of allergic inflammation. Because it is selectively expressed in ASM within the lung and does not promote inflammation, RGS5 might be a therapeutic target for asthma.

Keywords

AHR HASM PCLS ERK DAPI ASM PLCβ MLC GPCR TLR RGS PI3K 4′-6-diamidino-2-phenylindole dihydrochloride G protein–coupled receptor Asthma Aspergillus fumigatus BALF Toll-like receptor Regulator of G protein signaling myosin light chain Human airway smooth muscle Airway smooth muscle Phospholipase Cβ phosphoinositide 3-kinase Bronchoalveolar lavage fluid Lung resistance wild-type Airway hyperresponsiveness G proteins extracellular signal-regulated kinase