| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3197507 | Journal of Allergy and Clinical Immunology | 2014 | 20 Pages |
Abstract
These results provide the first evidence of a regulatory role for mitochondrial STAT3 in mast cell functions, and therefore mitochondrial STAT3 could serve as a new target for the manipulation of allergic diseases.
Keywords
STAT3protein inhibitor of activated STAT3CBMCBMMCPIAS3RBLDNPOXPHOSSDHDMSOERK1/2Small interfering RNAsiRNAAllergyDimethyl sulfoxideBone marrow–derived mast cellsuccinate dehydrogenaseCytokinesOxidative phosphorylationDegranulationRat basophilic leukemiaMast cellssignal transducer and activator of transcription 3Mitochondriaextracellular signal-regulated kinase 1 and 2
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Authors
Tal Hadad MSc, Zohar PhD, Gillian PhD, Alona Peretz, Helena PhD, Sagi MD, PhD, Hovav MD, PhD, Francesca PharmD, PhD, Ann PhD, Ehud PhD,