Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)

Article ID	Journal	Published Year	Pages	File Type
3197661	Journal of Allergy and Clinical Immunology	2014	22 Pages	PDF

Abstract

In summary, modifications at the DNA level of antigen-induced T-cell subsets might be predictive of a state of operationally defined clinical immune tolerance during peanut OIT.

Keywords

SPT LAG3 iTreg nTreg CD40L Tr1 CFSE DBPCFC Treg Induced regulatory T OFC APC Natural regulatory T MFI FOXP3 Food allergy Allergy antigen-presenting cell Epigenetics oral immunotherapy Peanut Skin prick test Tolerance Teff OIT Dendritic cell CD40 ligand Regulatory T mean fluorescence intensity forkhead box protein 3 Oral food challenge Double-blind, placebo-controlled food challenge Lymphocyte activation gene 3 Desensitization carboxyfluorescein succinimidyl ester

Related Topics

Life Sciences Immunology and Microbiology Immunology

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Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)

Authors

Aleena BSc, Marco A. BSc, Shu-Chen MSc, Robert BSc, Arunima BSc, Satoru PhD, Jelena P. PhD, Mindy DMSc, Holden PhD, Gerri RN, Stephen J. MD, Kari C. MD, PhD,