| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3197816 | Journal of Allergy and Clinical Immunology | 2013 | 24 Pages |
Abstract
This study describes a new role for IL-4 by demonstrating that moDCs are conditioned by IL-4 for the induction of TH2 responses by blocking TH1-polarizing/inflammatory cytokine production through histone hypoacetylation and upregulating TH2-related genes.
Keywords
TLREosinophil-associated ribonucleaseBMMΦTh2 responsesBMDCMoDCHDMPPARγiNOSHDACqPCRCTLTSACDCIL-4Monocyte-derived DCQuantitative PCRSTATchromatin immunoprecipitationTrichostatin AToll-like receptorDendritic cellBone marrow–derived dendritic cellconventional dendritic cellDendritic cellsMonocyte-derived dendritic cellsinducible nitric oxide synthasecytotoxic T lymphocyteMonocyte-derived macrophagealternatively activated macrophagebone marrow macrophageSignal transducer and activator of transcriptionNitric oxidehistone deacetylaseCHiPHouse dust miteEARperoxisome proliferator-activated receptor γ
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Authors
MarÃa PhD, MarÃa MSc, Pilar M. PhD, Leticia BSc, Carlos PhD, Pilar PhD, Gloria PhD, Carlos PhD,