Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3198249 | Journal of Allergy and Clinical Immunology | 2013 | 10 Pages |
Abstract
Thus in patients with CARD11 deficiency, the combination of impaired activation and especially upregulation of inducible T-cell costimulator on T cells, together with severely disturbed peripheral B-cell differentiation, apparently leads to a defective T-cell/B-cell cooperation and probably germinal center formation and clinically results in severe immunodeficiency. This report discloses the crucial and nonredundant role of canonical NF-κB activation and specifically CARD11 in the antigen-specific immune response in human subjects.
Keywords
NF-κBKRECPerCPCD40LBCL10BAFF-Rphorbol 12-myristate 13-acetateTregICOSMALT1APCinducible T-cell costimulatorERKCARD11TCrBCRFITCCIDgDNAnatural killergenomic DNATRECPMAallophycocyaninHumanT-cell receptor excision circlenuclear factor κBphycoerythrinfluorescein isothiocyanateCD40 ligandGerminal centerRegulatory T HypogammaglobulinemiaPeridinin-chlorophyll-protein complexCombined immunodeficiencyextracellular signal-regulated kinaseB-cell receptorT-cell receptor
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Authors
Polina MD, Baerbel MSc, Mary Buchta, Anne-Kathrin MSc, Orly MD, Raz MD, PhD, Sivan MSc, Idit PhD, Lisa A. PhD, Michael PhD, Ilka MSc, Anselm MD, Hermann PhD, Bodo MD, Klaus MD,