Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma

Article ID	Journal	Published Year	Pages	File Type
3198356	Journal of Allergy and Clinical Immunology	2012	14 Pages	PDF

Abstract

ASMCs of patients with severe asthma are corticosteroid insensitive; this might be secondary to heightened p38 mitogen-activated protein kinase levels.

Keywords

Jnk ASMC CX3CL1 CXCL8 Ccl11 qRT-PCR ERK NF-κB c-Jun N-terminal kinase MAPK Asthma chromatin immunoprecipitation Airway smooth muscle cell Airway smooth muscle nuclear factor κB quantitative real-time PCR mitogen-activated protein kinase CHiP extracellular signal-regulated kinase glucocorticoid receptor