| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3198436 | Journal of Allergy and Clinical Immunology | 2012 | 7 Pages |
Abstract
The IL6R coding SNP rs2228145 (Asp358Ala) is a potential modifier of lung function in subjects with asthma and might identify subjects at risk for more severe asthma. IL-6 transsignaling might have a pathogenic role in the lung.
Keywords
BALCSGASARPIL-6RATSFVCIL-6sIL-6RAsthmaSevere asthmaAmerican Thoracic SocietySevere Asthma Research ProgramGenetic variationforced vital capacityLinkage disequilibriumbronchoalveolar lavageGenome-wide association studyGWASCollaborative Study on the Genetics of AsthmaSingle nucleotide polymorphismSNPIL-6 receptorSoluble IL-6 receptor
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Authors
Gregory A. PhD, Mac B. PhD, Annette T. PhD, Xingnan PhD, Huashi MS, Wendy C. MD, Timothy D. PhD, William W. MD, Serpil C. MD, Sally E. MD, Stephen P. MD, PhD, Deborah A. PhD, Eugene R. MD, National Heart, Lung,