Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3198475 | Journal of Allergy and Clinical Immunology | 2012 | 11 Pages |
Abstract
Allergic asthma and allergic rhinitis/conjunctivitis are characterized by a TH2-dominated immune response associated with increased serum IgE levels in response to inhaled allergens. Because IgE is a key player in the induction and maintenance of allergic inflammation, it represents a prime target for therapeutic intervention. However, our understanding of IgE biology remains fragmentary. This article puts together our current knowledge on IgE in allergic airway diseases with a special focus on the identity of IgE-secreting cells (“who”), their location (“where”), and the circumstances in which they are induced (“when”). We further consider the therapeutic implications of the insights gained.
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Authors
Melissa Dullaers, Ruth De Bruyne, Faruk Ramadani, Hannah J. Gould, Philippe Gevaert, Bart N. Lambrecht,