| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3198478 | Journal of Allergy and Clinical Immunology | 2012 | 17 Pages |
Abstract
Sputum MMP-12 concentrations and activity in patients with COPD are directly associated with the extent of emphysema measured by means of CT. This finding supports a role for MMP-12 in the pathogenesis of COPD and might suggest that blocking MMP-12 activity in patients with COPD could prevent the further development of emphysema.
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Authors
Rekha MD, Charles PhD, Jeffrey PhD, Iona BSc, Christal PhD, Stephen BSc, Lisa BSc, Christopher J. PhD, C. Martina PhD, Mark PhD, Gino PhD, Karl PhD, Dan PhD, Joyce BSc, Maureen BSc, Jane BSc, Michael MBChB, William MD, Neil C. MD,