Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects

Article ID	Journal	Published Year	Pages	File Type
3198540	Journal of Allergy and Clinical Immunology	2012	17 Pages	PDF

Abstract

We identified a novel asthma-associated locus that is relevant to admixed populations with African ancestry and highlight the importance of considering local ancestry in genetic association studies of admixed populations.

Keywords

PC1 YRI SARP CSGA CEU Asthma African American first principal component Severe Asthma Research Program Admixed populations Population structure Linkage disequilibrium LAMP Genome-wide association study GWAS Admixture mapping Collaborative Study on the Genetics of Asthma Single nucleotide polymorphism Puerto Rican SNP Genetics of Asthma in Latino Americans GalA Yoruba in Ibadan, Nigeria

Related Topics

Life Sciences Immunology and Microbiology Immunology

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Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects

Authors

Dara G. PhD, Daniel BS, Elizabeth J. PhD, Xingnan PhD, Wendy C. MD, Christopher R. MS, Donglei PhD, Celeste BS, Rasika A. ScD, William W. MD, Mario MD, Serpil C. MD, Anne M. PhD, Benjamin MD, Elliot MD, Nizar N. MD, W. Gerald MD, Sally E. MD, Dan L. PhD,