| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3198558 | Journal of Allergy and Clinical Immunology | 2012 | 12 Pages |
Abstract
The engagement of OX40L selectively suppresses Fyn-initiated signals required for MC degranulation and serves to limit immediate hypersensitivity. Our data suggest that soluble OX40 can restore the aberrant or absent regulatory T-cell activity, revealing a previously unappreciated homeostatic role for OX40L in setting the basal threshold of MC response.
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Authors
Riccardo PhD, Barbara PhD, Ryo PhD, Federica MSc, Giorgia PhD, Silvia PhD, Mario P. PhD, Juan PhD, Carlo E. MD,