| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3198627 | Journal of Allergy and Clinical Immunology | 2012 | 23 Pages |
Abstract
These results elucidate a novel innate allergen-recognition pathway mediated by naive T cells through PAR2, which provide an immediate source of chemokines and IL-4 upstream of basophils and antigen-restricted TH2 differentiation. PAR2 antagonism might thus hold promise for the treatment of allergic disease.
Keywords
qPCRBMBTh2PLNAPCOVAFITCJanus kinaseQuantitative PCRAllergensSTATantigen-presenting cellOvalbuminbasophilsParDendritic cellphycoerythrinfluorescein isothiocyanateMast cellSignal transducer and activator of transcriptionbone marrowwild-typeJAKChemokinesChemotaxisPopliteal lymph nodeLymph nodeprotease-activated receptor
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Authors
Genqing PhD, Tolga PhD, Zhihui PhD, Nicolas PhD, Juan PhD, Kirk M. MD,