Eosinophilic esophagitis: Epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment

Article ID	Journal	Published Year	Pages	File Type
3198628	Journal of Allergy and Clinical Immunology	2012	17 Pages	PDF

Abstract

EMT likely contributes to subepithelial fibrosis in subjects with EoE and resolves with treatments that decrease esophageal inflammation, and its resolution correlates with decreased numbers of esophageal eosinophils.

Keywords

SFED PPI RT-Q-PCR EPX hpf EoE Vimentin GERD Eosinophil eosinophil peroxidase EoE, Eosinophilic esophagitis Esophagitis epithelial mesenchymal transition Remodeling Epithelium gastroesophageal reflux disease EMT elemental diet six-food elimination diet cytokeratin Fibrosis mesenchymal Proton pump inhibitor high-power field Topical corticosteroid

Related Topics

Life Sciences Immunology and Microbiology Immunology

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Eosinophilic esophagitis: Epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment

Authors

Amir F. MD, Noorain MD, Samantha A. MD, Bryan A. BA, Joanne C. PhD, Vincent MD, Kalyan R. MD, Jian MD, Sophie PhD, Cheryl A. BA, James J. PhD, Katie BS, Hector MD, Kelley E. MD, Glenn T. MD, Steven J. PhD,