Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways

Article ID	Journal	Published Year	Pages	File Type
3198682	Journal of Allergy and Clinical Immunology	2012	19 Pages	PDF

Abstract

IMQ TLR8 agonists engage adenosine-refractory TLR8 and inflammasome pathways to induce robust monocyte and MoDC activation and represent promising neonatal adjuvants.

Keywords

NF-κB MALP PDC IMQ dibutyryl-cAMP CBMC caspase-1 NLRP3 MoDC APC IL-1β db-cAMP MDC TLR cAMP Small interfering RNA siRNA Adenosine Cyclic adenosine monophosphate Alum antigen-presenting cell Adjuvant Inflammasome Innate immunity Imidazoquinoline Toll-like receptor Cord blood mononuclear cell Dendritic cell Plasmacytoid dendritic cell Myeloid dendritic cell Monocyte-derived dendritic cell nuclear factor κB Newborn Neonate Toll-like receptor 8

Related Topics

Life Sciences Immunology and Microbiology Immunology

$Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways$

Authors

Victoria J. DPhil, David J. PhD, Leighanne C. BSc, Guadalupe PhD, Zhen MD, Eugénie E. MA, Kevin W. BA, Ariel MPH, Liat MSc, Mark PhD, Richard L. PhD, Keith DVM, Ofer MD, PhD,