Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy

Article ID	Journal	Published Year	Pages	File Type
3198684	Journal of Allergy and Clinical Immunology	2012	17 Pages	PDF

Abstract

The results of this pilot study suggest that dual SLIT could be an effective means to treat subjects with sensitivities to a variety of allergens and that long-term tolerance might be induced by epigenetic modifications of Foxp3 in memory regulatory T cells.

Keywords

GITR CTLA-4 Glucocorticoid-induced TNF receptor SLIT FOXP3 Treg NDC PD-1 Respiratory allergies cytotoxic T-lymphocyte antigen 4 Epigenetics Sublingual immunotherapy Teff GPS Regulatory T cell Programmed death 1 Regulatory T forkhead box protein 3 Timothy grass dust mite

Related Topics

Life Sciences Immunology and Microbiology Immunology

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Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy

Authors

Ravi S. MD, Neha MD, Tessa BSc, Soujanya MD, Carah B. MD, Fuad M. MD, Peter H. MD, Elisabeth G. NP, Marco A. BSc, Kari C. MD, PhD,