Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3198957 | Journal of Allergy and Clinical Immunology | 2012 | 11 Pages |
Abstract
Interactions between exposure to ambient air pollutants and respiratory pathogens have been shown to modify respiratory immune responses. Emerging data suggest key roles for Toll-like receptor (TLR) and nucleotide-binding oligomerization domain–like receptor (NLR) signaling in pathogen-induced immune responses. Similarly, immune responses elicited by exposure to air pollutants are mediated by specific TLR- and NLR-dependent mechanisms. This review article will summarize current knowledge about how air pollutants modify TLR- and NLR-dependent signaling and host defense responses in the lung.
Keywords
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Authors
Rebecca N. Bauer, David Diaz-Sanchez, Ilona Jaspers,