Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3199035 | Journal of Allergy and Clinical Immunology | 2011 | 12 Pages |
Abstract
By providing a limitless source of diseased stem cells that can be differentiated into various cell types in vitro, the repository of iPSC lines from patients with PIDs represents a unique resource to investigate the pathophysiology of hematopoietic and extrahematopoietic manifestations of these diseases and might assist in the development of novel therapeutic approaches based on gene correction.
Keywords
KLF4cMYCRAG1Sox2Oct4SCIDIPSCqRT-PCRbFGFPIDHEShuman embryonic stemReprogrammingInduced pluripotent stem cellsInduced pluripotent stem cellbasic fibroblast growth factoroctamer-binding transcription factor 4Sex determining region Y-box 2quantitative real-time polymerase chain reactionprimary immunodeficiencySevere combined immune deficiency
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Authors
Itai M. MD, PhD, Jose BA, Shen-Ying MD, Jean-Laurent MD, PhD, Silvia PhD, Andrew R. MD, Waleed MD, Philip D. PhD, Thorsten M. PhD, In-Hyun PhD, Francesca PhD, Suneet MD, PhD, Gustavo MD, PhD, George Q. MD, Luigi D. MD,