Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3199066 | Journal of Allergy and Clinical Immunology | 2011 | 18 Pages |
Abstract
The current study demonstrates that IL-4 induces differentiation of stem/precursor cells into fibroblast-like cells that demonstrate a more fibrogenic phenotype, which is due to reduced expression of miR-155. These findings provide a novel mechanism for the persistent abnormalities in IL-4-related diseases and a novel target to regulate tissue remodeling by fibroblasts.
Keywords
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Authors
Tadashi MD, PhD, Xiangde MD, Hesham PhD, Shinsaku MD, PhD, Hisatoshi MD, PhD, Amy BS, Masanori MD, PhD, Nobuhiro MD, PhD, Xingqi MD, Miok MD, Yingji MD, PhD, Joel BS, Maha MD, John G. PhD, Stephen I. MD,