Article ID Journal Published Year Pages File Type
3199066 Journal of Allergy and Clinical Immunology 2011 18 Pages PDF
Abstract
The current study demonstrates that IL-4 induces differentiation of stem/precursor cells into fibroblast-like cells that demonstrate a more fibrogenic phenotype, which is due to reduced expression of miR-155. These findings provide a novel mechanism for the persistent abnormalities in IL-4-related diseases and a novel target to regulate tissue remodeling by fibroblasts.
Related Topics
Life Sciences Immunology and Microbiology Immunology
Authors
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