| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3199255 | Journal of Allergy and Clinical Immunology | 2011 | 12 Pages |
Abstract
Hyaluronan homeostasis is deranged in asthma, with increased production by fibroblasts and decreased CD44 expression on alveolar macrophages. Upregulation of TLR2 and TLR4 on macrophages with increased sensitivity to hyaluronan fragments suggests a novel proinflammatory mechanism by which persistence of hyaluronan fragments could contribute to chronic inflammation and airway remodeling in asthma.
Keywords
bHABPphorbol 12-myristate 13-acetateHASTLRBALECMPMANOxROSAsthmaBALFToll-like receptorCytokinesFibroblastsbronchoalveolar lavageExtracellular matrixMacrophagesBronchoalveolar lavage fluidnicotinamide adenine dinucleotide phosphate oxidaseHyalHyaluronanHyaluronan synthaseHyaluronidaseReactive oxygen species
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Authors
Jiurong MD, Dianhua MD, PhD, Yoosun MS, Ting MD, Jennifer PhD, Tony BS, Simone PhD, Maura BS, Monica MD, Paul W. MD,