| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3199304 | Journal of Allergy and Clinical Immunology | 2010 | 12 Pages |
Abstract
We show here that inhibition of IgE production by calcitriol is mediated by its transrepressive activity through the VDR-corepressor complex affecting chromatin compacting around the Iε region. Our findings shed new light on mechanisms of VDR transrepression and understanding of IgE regulation.
Keywords
TRPV6RARRXRVDREVDRRetinoid X receptorCYP27B1As2O3qRT-PCRHDACSMRTORFIgECSRTSSNCoRAcetylated histoneGLTquantitative RT-PCRAChHistone acetylationchromatin immunoprecipitationSilencing mediator for retinoid and thyroid hormone receptorsTranscription startvitamin D response elementopen reading frameclass-switch recombinationnuclear receptor corepressorhistone deacetylaseSingle nucleotide polymorphismSNPCHiPCalcitriolRetinoic acid receptorVitamin D receptor
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Authors
Milena MD, Guido MD, Werner PhD, Bastian MD, Andreas PhD, Margitta MD,