| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3199455 | Journal of Allergy and Clinical Immunology | 2011 | 11 Pages |
Abstract
PNP is important for the survival of DP thymocytes. Accumulation of dGuo in cases of PNP deficiency leads to mitochondria-initiated apoptosis of DP thymocytes, which can be prevented by restoring PNP activity in the cells.
Keywords
HSCDeoxyguanosine monophosphatedGMPdGuodGTPDGK5-bromo-2-deoxyuridinePNPTCrMMPFACSadenosine deaminaseBrdUProliferationsingle positiveThymocytesApoptosisfluorescence-activated cell sortingDouble negativedouble positivedeoxyguanosine triphosphateDeoxyguanosine kinaseDeoxyguanosineHematopoietic stem cellMiceADAMitochondrial membrane potentialPropidium iodidePurine nucleoside phosphorylaseimmune deficiencyT-cell receptor
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Authors
Taniya MSc, Wexian MSc, Suntharalingam BSc, Amos PhD, Cameron PhD, Chaim M. MD, Eyal MD,