Prediction of IgE-binding epitopes by means of allergen surface comparison and correlation to cross-reactivity

Article ID	Journal	Published Year	Pages	File Type
3199457	Journal of Allergy and Clinical Immunology	2011	16 Pages	PDF

Abstract

Our approach is the first for the prediction of IgE epitopes by combining structural and IgE cross-reactivity data. It should be useful for the development of point-mutated or structurally disrupted allergen derivatives for allergen-specific immunotherapy.

Keywords

RMSD PDB PR-10 SPADE IgE binding Allergy SES Allergen-specific immunotherapy Bovine β-lactoglobulin X-ray structures Cross-reactivity Protein Data Bank Epitope prediction