| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3199515 | Journal of Allergy and Clinical Immunology | 2010 | 18 Pages |
Abstract
The results point to increased activity of the 15-LO inflammatory pathway in childhood asthma. Mass spectrometric analyses of EBC demonstrate that increased eoxin levels not only accompany the increased 5-LO product LTC4 but are also associated with BHR. These markers might represent a new therapeutic target for asthma treatment.
Keywords
FeNOFEF25-75ICSCysteinyl leukotrieneCysLTEBCLTRAFVCECPBALBHRAsthmaLeukotriene receptor antagonist15-hydroxyeicosatetraenoic acidhydroxyeicosatetraenoic acidfractional exhaled nitric oxideSEARCHbody mass indexBMIMass spectrometryforced vital capacitybronchoalveolar lavageLeukotrienesLeukotrienelipoxygenaseExhaled breath condensateHETEBronchial HyperresponsivenessPalmitic acidEosinophilic cationic proteinChildInhaled corticosteroid
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Authors
Christine MD, Marek MD, Astri Maria MD, Anna MSc, Petter MSc, Karin Cecilie MD, Kai-HÃ¥kon MD, Andrzej MD,