Article ID Journal Published Year Pages File Type
3199612 Journal of Allergy and Clinical Immunology 2011 19 Pages PDF
Abstract
This noninvasive, semiquantitative profiling method has revealed novel proteins likely involved in the pathogenesis of AD. The lower expression of skin barrier proteins and enzymes involved in the generation of the natural moisturizing factor could further exacerbate barrier defects and perpetuate water loss from the skin. The greater expression of epidermal fatty acid-binding protein, especially in patients colonized with methicillin-resistant S aureus, might perpetuate the inflammatory response through eicosanoid signaling.
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