| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3199621 | Journal of Allergy and Clinical Immunology | 2011 | 14 Pages |
Abstract
Excessive mucus production and mucus plugging are key pathologic features of asthma, yet the mechanisms responsible for mucus production are not well understood. Our data reveal a novel nonredundant role for Serpinb3a in mediating mucus production through regulation of SPDEF expression. This pathway may be used to target mucus hypersecretion effectively.
Keywords
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Authors
Umasundari PhD, David J. PhD, Mark B. BS, Aaron M. BS, Matthew T. Stier, Eric B. PhD, Stacey A. Bass, Michael O. MD, Jamila PhD, Keith F. MD, Susan E. PhD, Jeffrey A. MD, Timothy D. PhD, Marsha PhD, Gary A. MD, PhD, Gurjit K. MD, PhD,