| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3199746 | Journal of Allergy and Clinical Immunology | 2010 | 8 Pages |
Abstract
IgE, mast cells, basophils, and eosinophils are essential components of allergic inflammation. Antigen-specific IgE production, with subsequent fixation of IgE to FcεRI receptors on mast cells and basophils, is central to the initiation and propagation of immediate hypersensitivity reactions. Mast cells, basophils, and eosinophils are central effector cells in allergic inflammation, as well as in innate and adaptive immunity. This review highlights what is known about these components and their roles in disease pathogenesis.
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Authors
Kelly D. Stone, Calman Prussin, Dean D. Metcalfe,