Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3199751 | Journal of Allergy and Clinical Immunology | 2010 | 13 Pages |
Abstract
Drug allergy is one type of adverse reaction to drugs and encompasses a spectrum of hypersensitivity reactions with heterogeneous mechanisms and clinical presentations. A thorough history is essential to the management of drug allergy. Laboratory testing has a very limited role in the management of drug allergy. Graded dose challenges and procedures to induce drug tolerance might be required in patients with drug allergy when there is a definite need for a particular agent. Management of reactions to specific agents, including β-lactam antibiotics, sulfonamides, local anesthetics, radiocontrast media, angiotensin-converting enzyme inhibitors, nonsteroidal anti-inflammatory drugs, and biologic modifiers, will be discussed in further detail.
Keywords
RCMADRACE-IAERDNSFNSAIDTMP-SMXSJSASAPPLAspirin-exacerbated respiratory diseaseangiotensin-converting enzyme inhibitorsacetylsalicylic acidDrug rash with eosinophilia and systemic symptomsLocal anestheticTrimethoprim-sulfamethoxazoleToleranceDrug AllergyDrug hypersensitivitynonsteroidal anti-inflammatory drugtenradiocontrast mediaCephalosporinStevens-Johnson syndromeSulfonamideAdverse drug reactionnephrogenic systemic fibrosisDRESSangiotensin-converting enzyme inhibitorToxic epidermal necrolysisAdverse drug reactionsPenicillinCarbapenemDesensitization
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Authors
David A. MD, Roland MD,