Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3199766 | Journal of Allergy and Clinical Immunology | 2010 | 9 Pages |
Abstract
Primary immunodeficiencies are congenital disorders caused by defects in different elements of the immune system. Affected patients usually present clinically with recurrent infections, severe infections, or both, as well as autoimmune phenomena that are associated with many of these disorders. Early diagnosis is essential for referral to specialized care centers and the prompt initiation of appropriate therapy. In this article the authors describe a general approach for the investigation of the most common primary immunodeficiencies, outlining the typical clinical symptoms and most appropriate laboratory investigations.
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Authors
João B. Oliveira, Thomas A. Fleisher,