| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3199837 | Journal of Allergy and Clinical Immunology | 2011 | 13 Pages |
Abstract
EDA-FN is essential for the development of OVA-induced airway fibrosis and AHR. The effect of the EDA domain on airway fibrosis after OVA challenge is through activation and differentiation of fibroblasts. Fibroblast activation and airway fibrosis are necessary for the development of AHR.
Keywords
extra domain BASMOVABALIODextra domain ARGDEDAAHRα-SMAECMcycle thresholdAsthmaperiodic acid–SchiffOvalbuminα-smooth muscle actinAirway remodelingintegrated optical densityAirway smooth muscleFibroblastFibrosisbronchoalveolar lavageExtracellular matrixEDBMyofibroblastPASwild-typeAirway hyperresponsiveness
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Authors
Martin MSc, Andres F. PhD, Reem MSc, Neville MBBCh, FRCP,