Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3199903 | Journal of Allergy and Clinical Immunology | 2011 | 20 Pages |
Abstract
These data show that the C104R mutation and its murine equivalent, C76R, can significantly disrupt TACI function, probably through haploinsufficiency. Furthermore, the heterozygous C76R mutation alone is sufficient to disturb B-cell function with lymphoproliferation and immunoglobulin production defects.
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Authors
Chiara PhD, Karen F. PhD, Sylvie BSc, Ulrich MD, Pascal PhD, Adrian J. MD, PhD, H. Bobby MD, PhD,