| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3200019 | Journal of Allergy and Clinical Immunology | 2010 | 19 Pages |
Abstract
Genes involved in the development and function of regulatory T cells, specifically IL2RA, TLR2, TGFBR2, and FOXP3, associate with atopy and asthma by gene-gene interaction. Modeling of multiple gene-gene interactions is important to unravel further the genetic susceptibility to atopy and asthma.
Keywords
TLRTGFBRheme-oxygenase 1PIAMAHMOX1TregFDRIgEMDRFOXP3Specific IgEAtopyAsthmaInteractionToll-like receptorT regulatory cellsRegulatory T false discovery rateodds ratioforkhead box protein 3PolymorphismSingle nucleotide polymorphismPrevention and Incidence of Asthma and Mite AllergySNPMultifactor dimensionality reductionKOALABirth cohortsIgETGF-β receptor
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Authors
Renske W.B. MD, Marjan MD, PhD, Naomi E. MD, Carel MD, PhD, Henriette A. PhD, Constant P. PhD, Bert PhD, Antoon J. PhD, Dirkje S. MD, PhD, Gerard H. MD, PhD,