Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3200087 | Journal of Allergy and Clinical Immunology | 2010 | 10 Pages |
Abstract
Parenteral antigen-induced murine systemic anaphylaxis is mediated by both IgG- and IgE-dependent pathways, and both can occur independently of IL-9/IL-9R signaling. In contrast, oral antigen-induced intestinal and systemic anaphylaxis is strictly IgE mediated and requires IL-9/IL-9R signaling. These studies indicate differential involvement of the IL-9/IL-9R pathway in systemic and oral antigen-induced anaphylaxis.
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Authors
Heather BSc, Richard BSc, Richard MD, Fred D. MD, Jean-Christophe PhD, Simon P. PhD,