| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3200139 | Journal of Allergy and Clinical Immunology | 2009 | 11 Pages |
Abstract
Subjects with severe asthma with chronic persistent obstruction have increased airway smooth muscle with ongoing TH1 and TH2 inflammatory responses. Neither airway measurements on high-resolution computed tomographic scans nor sputum analysis seem able to identify such patients.
Keywords
FeNOReticular basement membraneWA%ECPHRCTATSASMMMPMIPMCPMPOSevere asthmainflammationAmerican Thoracic Societytissue inhibitor of matrix metalloproteinaseRemodelingBiopsyhigh-resolution computed tomographycomputed tomographyFraction of exhaled nitric oxideSputumSMATIMPRBMCytokinesAirway smooth muscleFibrosismatrix metalloproteinasemyeloperoxidasemonocyte chemotactic proteinmacrophage inflammatory proteinEosinophil cationic protein
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Authors
Marta MD, Susan MD, Karim DSc, PhD, Claudine BSc, Harvey PhD, Heberto PhD, Catherine MD, MSc, Ronald MD, Pierre MD, Qutayba MD, PhD, James MD, DSc,