| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3200454 | Journal of Allergy and Clinical Immunology | 2009 | 18 Pages |
Abstract
The data support a role for SphK1 and S1P in allergen-induced airway inflammation. However, SphK1 deficiency increased pulmonary vascular hyperresponsiveness, which is a component of PAH pathobiology. Moreover, we show for the first time the dissociation between inflammation-induced remodeling of the airways and pulmonary vasculature.
Keywords
PAHSphK1OVABALS1P1HprtS1PPPAMCHSphingosine kinaseSphingosine kinase 1Sphingosine-1-phosphate lyasesphingosine 1-phosphateOvalbuminVascular remodelinggranulocyte colony-stimulating factorG-CSFPulmonary arterial hypertensionPulmonary arterial pressurebronchoalveolar lavageMethacholinewild-typehypoxanthine guanine phosphoribosyl transferasethreshold cycle
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Authors
Rainer V. PhD, Christoph Tabeling, Sue PhD, Birgitt Gutbier, Peter MD, Manfred PhD, Hartwig MD, Norbert MD, Ian PhD, Martin MD,