Mannose-binding lectin and mannose-binding lectin-associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults

Article ID	Journal	Published Year	Pages	File Type
3200541	Journal of Allergy and Clinical Immunology	2008	9 Pages	PDF

Abstract

Our large study suggests that MBL plays a redundant role in human defenses against primary infection, at least in adults with CAP, and provides, for the first time, evidence that MBL insufficiency predisposes to higher severity and fatal outcome in patients with CAP, irrespective of the causal microorganisms.

Keywords

SSH MODS MBL PGN MASP-2 ARF ARDS ICU intensive care unit Multiple organ dysfunction syndrome Acute respiratory distress syndrome Sepsis Severe sepsis Septic shock Mannose-binding lectin lectin pathway Acute respiratory failure odds ratio Community-acquired pneumonia Peptidoglycan CaP primary immunodeficiency

Related Topics

Life Sciences Immunology and Microbiology Immunology

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Mannose-binding lectin and mannose-binding lectin-associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults

Authors

M. Isabel BSc, Jordi PhD, Felipe Rodriguez PhD, Javier PhD, M. Luisa PhD, Ayoze BSc, Olga PhD, Jose PhD, Araceli BEc, J. Alberto MD, Javier BSc, Carlos PhD,